Intravenous zoledronate for osteoporosis: less might be more
نویسندگان
چکیده
منابع مشابه
Macromolecular crowding in vitro as means of emulating cellular interiors: when less might be more.
Fascinating evidence was presented recently that monocrowding with Ficoll 70 (Fc70) improves the refolding speed of VlsE that was unfolded in urea (1). This demonstrated the power of macromolecular crowding as present in cellular interiors. However, we noted that the Fc70 concentrations used in this study (1) are high enough to cause self-crowding (2), meaning compaction of the crowder, thus di...
متن کاملMetronomic Chemotherapy: When Less May Be More
The use of low dose continuous schedules of chemotherapy (i.e. metronomic chemotherapy), delivered at lower doses by necessity compared to traditional dosing schemes, has become an increasingly popular addition to patient management in veterinary medical oncology. While the concept itself is not new, as low dose, maintenance chemotherapy protocols have been important components of treatment for...
متن کاملTreatment of Transient Osteoporosis of the Hip with Intravenous Zoledronate - A Case Report -
Transient osteoporosis of the hip (TOH) is a rare disorder of unknown etiology that is characterized by acute onset of disabling bone pain. The locally increased bone turnover and low bone mineral density (BMD) associated with this disorder indicate a potential role for an antiresorptive agent such as bisphosphonate as a treatment. A previously healthy 46-year-old man developed the sudden onset...
متن کاملFavorable therapeutic response of osteoporosis patients to treatment with intravenous zoledronate compared with oral alendronate
OBJECTIVES To evaluate the efficacy of orally-administered alendronate compared with intravenously-administered zoledronate. METHODS This prospective study was carried out at Barts Health HNS Trust between April 2010 and March 2012. This study compares changes in bone mineral density (BMD) in 234 patients treated with 2 bisphosphonates: alendronate taken orally, and zoledronate administered i...
متن کاملHigh-Dose Antiangiogenic Therapy for Glioblastoma: Less May Be More?
John F. de Groot Author’s Affiliations: Brain Tumor Center and Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX Running Title: Dosing effects of antiangiogenic therapy in glioblastoma
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Therapeutic Advances in Musculoskeletal Disease
سال: 2016
ISSN: 1759-720X,1759-7218
DOI: 10.1177/1759720x16650866